Mini splits. And yes they’re ugly.
you can do it with your main hvac system as long as they run individual ducts to every room (which they should). You decide how many zones you want. And go
From there.
Each vent will have a built in electronic damper, not at the ceiling or wall vent but in line with the duct work.
You’ll have a Smart Control board installed next to your hvac unit, that will connect all the thermostats (you can use any thermostat you want ). Then the control board will tell your hvac system to run cool or heat and tell which dampers to open or stay closed, directing airflow to the zones you prefer.
HVAC Zone Control Supply - Source for the best Zoning Controls & Zone Dampers available. SmartZone controls comfort everywhere while reducing heating and cooling needs.
zoningsupply.com
This is the company I used and have been happy so far. It’ll give you a better idea of what I’m talking about.
Lastly you’ll need something called a dump vent. Let’s say your entire house is up to temp but you want your bedroom colder. Well that will only open a handful of dampers while the the rest are closed and restricting airflow across your whole house HVAC unit. You’ll need all the airflow you can get for it to operate properly. A dump vent will open to allow the extra air flow.. that dump vent would likely be most suitable in the garage.