With a disabler plugged in, or AFM turned off in the ECM..... And all of the AFM hardware still installed in the engine.... It will drive as if it does not have AFM. (As long as the AFM components are in working order when you disable AFM. )
As to deleting the AFM hardware and starting the engine without turning off AFM in the computer.... It should still run, although with drivability issues exactly what the original poster has described. The problems would occur when the ECM is altering the parameters to activate AFM. Remember, AFM is not active at idle, or over a certain engine load. (More than one quarter throttle, and probably over a certain RPM. 2000 RPM sounds about right)
In the AFM deletes I do, I replaced the AFM camshaft with an oem camshaft designed for the engine prior to the implementation of AFM. For example in an L94, I use the camshaft out of an L92. If the AFM were not turned off, at least the other four cylinders are what the ECM expects to see.
Now if you were to go the aftermarket camshaft, you're changing the entire camshaft profile on all 8 cylinders. You're altering the duration and probably the lift as well. If you do not disable AFM and program the ECM for the new camshaft, and turning off VVT if you deleted it, I can easily see why that combination would not start. The fueling and timing would be way off. That is why in this scenario you pretty much have to start with a base tune to get it started and running..... And then fine tune it after collecting some data.
In all of the AFM deletes I've done, the people just wanted it gone..... Keep the same horsepower and fuel mileage..... And they wanted it to last.
Nothing wrong with going for the aftermarket camshaft with higher lift, you can add significant horsepower. Like every other engine that comes at a cost. Long-term engine life basically. It's more stress on the cam bearings and the valve train components more than anything. The bottom end of the LS engine isn't so much of an issue.
One thing I've seen time after time on AFM deletes using an oem camshaft..... In every instance fuel mileage has increased. (Usually between 1 and 1.5 MPG.) It appears the AFM system fails miserably at what it was intended to do.... To increase fuel economy. Perhaps it helped in the first 50,000 miles, but it seems clear after that it's a pointless complication that kills engines.