Marky Dissod always has great input in this category.
Because I'm quite possibly THE ONE & ONLY duhmass who INCREASED V4 mode's duty cycle, above & beyond GM's original intent.
Used to drive a 2012 Yukon XL SLT (leased) as a NYC livery vehicle. Mostly driven in NYC, so, to discourage myself from driving leadfooted,
I asked my tuner to make even more use of V4 mode than GM did. (GM wanted no one, not even the driver, to ever hear or feel any indications or hints of it.)
We wound up with V4 mode enabled in 3rd 4th 5th & 6th. Under about 15%TPS, V4 mode was probably in effect on level ground or a downhill.
Even without V4 mode lit in the instrument panel,
I sometimes barely felt it, but no one else ever noticed or commented, so I thought we got it right.
For ONE YEAR, fuel economy improved, by about 2-3 city MpG, & 1-2 highway MpG. (Truly conservative driving / hypermiling
MIGHT have yielded better results?)
FYI, oil was changed once a month / every 2500-3000 miles, as they were mostly accrued in Manhattan stop'n'sit'n'go-slow-then-stop-again traffic.
MpG benefits faded over time, even with the engine Half@$$ing itself far more than any of you might believe.
(Often wonder if Cylinder Deactivation @ 0%TPS might actually be the WORST thing ever, for both Engine Half@$$
& Cylinder Confusion ...)
Some time after the MpG benefits faded to nil, despite my increasingly daisy driving, started noticing oil consumption one summer.
By winter, the oil consumption had risen to a quart a week - as in, 1qt every 1000 miles OR LESS.
Moral of the above story: my experiences with more Engine Half@$$ than any of you have convinced me that 3.42 / 3.73 / 4.10
will let the engine spend more time in 5th & 6th gears, which will improve MpG moreso than Engine Half@$$,
AND will protect the engine from eventually coking up the rings which Engine Half@$$ directly causes.
There is, however, ONE possible benefit to Engine Half@$$ / Cylinder Confusion ...