I asked my friend who is a 30+ year master GM mechanic about these motors. Mind you, he's the top tech in a busy shop that does ALL the hard, heavy, everything engine, diesel, and transmission work......
"The fuel economy is awesome and they are nice trucks.....if you're not the person who has to pay to fix or maintain them when it comes due. 18 hours shop labor to replace the oil pump belt at 150k. If/when the timing chains (yes, plural) go bad, it's a 50 hour shop rate job to do. It's cheaper at that point to put a new motor in it." His words, and I consider him my GM guru. He knows more about anything GM than anyone I've ever met, or worked with.
Take it for what it's worth.
He just bought a 212k mile 2021, 3500HD that was taken in on a trade. He did all the service on it since day 1 for the owner. Gets 16-17 mpg on the highway, 12.5 around town. No CAFE garbage, 6 speed transmission, doesn't burn oil, and the oil change costs the same as any LT motor. He's also not a fan of the new 10 speeds, hence picking up the high mileage 6 speed truck.