Smaller line is your high side. Never had any of the lines leak on any of my 4 K chassis. Once you remove line make sure you lube all sealing o rings with compressor lube oil. The system will have to be pumped down with a vaccuum pump and leak checked then charged with proper amount of R134A refrigerant. There will be a sticker underneath your hood that shows the proper weight of refrigerant in the system.
Since you have the system already open now is a good time to go ahead and change the orifice tube which is essentially similar to a jet in a LP/Natural gas furnace or oven. They dont look the same but do the same thing. It is located right in between your high and low side schrader valves. There is a big fitting right on the metal line between the schrader valves. Just unscrew that and pull the old orifice tube out and replace with new.
Heres a video on where it is and how to get it out.