I want to give them a try on a few of the more gnarly trails I always avoid with the Yukon. There are a few trails we have never hiked because we couldn't get to the trail heads.
The biggest negative right now with the Duratracs is they are pretty loud on the highway and are only going to get louder as they wear (I plan to rotate them every 5K faithfully). The fuel mileage does take a small hit, but they are a really stout tire. In the grand scheme of things, at my age, an mpg or two less is only going to hurt our daughters inheritance.
If I get really fed up with the noise (or I get to 30K miles and can't hear the radio..), I may switch to something like Michelin LTX AT2's. A compromise between decent off road and much quieter and better mileage tire.
But for now, it is just a lifted big old honking mother of a truck.