i think 4.10 would be a bit much for daily driving around where i live. while towing would be awesome but i think 3.73 would be best.
NO, 4.10 would be better than 3.73. You'd just spend more time in 6th, as well as in 5th, and downshift less often, assuming you're not a leadfoot.
For a potentially very small highway MpG penalty, your 6L80 would become stronger and last longer by shifting less often.
If you use your leadfoot to try to trade away some strength and durability, it'll still be stronger / more durable than 3.73, plus you'll gain MORE 'smiles per gallon'.
Or you could revise the 6L80 tune (shift pattern) to mitigate the small highway MpG loss.
Ever heard of the 2011-2017 Caprice PPV? Frequent the 'newcaprice' forum, you'll eventually learn that CAFE MpG pressures forced GM to settle for a 2.92 axle.
GM's original intent for the Caprice PPV was a 3.45 axle.
If you've the patience to do some maths, you'll eventually learn that
3.45 axle & 235/50R18 tires (27.25" tall) are near as makes no difference to 4.10 axle & 265/70R17 tires (31.60" tall).
Caprice PPVs, however, get 6.0L V8s and never tow anything.
Your Y-D
XL weighs at least 1000lb more & has worse drag area than a Caprice PPV, and a 5.3L vs the PPV's 6.0L,
yet you're favoring CAFE MpG's opinion over GM's on which axle gear to choose?
Think about it, then reread
@Joseph Garcia's post ... then reread
@SpareParts' post.