AFM/DOD is designed to meet Federal regulations, for emissions and for fuel economy. Pure and simple. for around $100 you can have it disabled by a tuner, and be done with it.
The problem with DOD is the lifter collapses in on itself. After so many cycles, the lifter begins to wear and then it gets jammed. My 2006 Rainier V8 lost #1 intake, and I fixed it, cost me about $400 or so for gaskets and a reprogrammed ECM. I did it over a weekend, but the ECM took about a week to ship out and ship back.
I did have a Check Engine Light when it failed. I unplugged the injector because I thought it did not make sense to have fuel squirting into the cyl, which made things worse, then the trans would not shift correctly, so I plugged it back in.