I installed mine (Range Technology DFM Disabler) today on my 25 Tahoe High Country 6.2L
Leaving wheel on but turning outward gives you room but I had 5 mini HEX trim screws to get out and then one bolt underneath. Its hard to get access to that module and detaching the OEM harness because fully extended you cant get much leverage. Taking wheel off would make it way easier.
One PRO TIP for those with the Advanced Security Package, when you disconnect NEG lead on main battery it sets off the piercing siren thats attached to the secondary battery thats hidden to power the Advanced Security Features. Scared the living Sh#! out of me and you cant disconnect that I know of.
I think truck runs better but could be placebo affect only time will tell.