^ Are you sure $450 for the tune? What are you getting?
You say you want a big difference. Do not expect a large increase in power. The main thing is drivability - better throttle response, better tranny shifting, a little bit more power, and maybe a little bit of fuel economy (if you can keep your foot off the skinny pedal
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What mods do you have engine wise? It would be better to have an aftermarket intake, at least change out the muffler (Magnaflow or Corsa), and remove the resonator (if you have the 5.3L engine) to take advantage of the tune.