No, it does not make sense. Half full (If truly half full) means you have at least 2-3000 miles of range left. I believe there is a software update out there for erroneous DEF readings. The least of which you should trust is Onstar warnings.
If things are working as they should you should get a warning on the vehicle DIC with say roughly 1000 miles range left to go. Kind of like a preliminary warning. Then at 500 miles to go, it gets a little more serious and starts counting down to zero. In most cases, I drive my vehicle until I get the first warning. Then dump in two and a half gallons from Walmart and motor on.
The only time the above rules don't apply is when you are towing with the vehicle. If you are towing, especially somewhat heavy, it takes down DEF at 2 or three times the rate of normal driving without a load.