From what I have heard, it's best to bring a front wheel/tire to the rear and always put the spare in the front.
The manual will tell you to just replace it, and get it fixed right away.
I would put the spare on the rear axle if I knew I was going to be driving around for a little while. If any wheel is going to blow its going to be that little 50 miles max 55pmh rated spare. If its going to go, you don't want it on a wheel that is controlling your steering. If you are not fully in control of the steering wheel, (knee driving, checking your phone, radio, busy with something in the vehicle, etc..), and it blows it will pull your vehicle to that side with quite a bit of force. If you are going fast enough it could cause a spin.
If its on the rear, all its going to do is be more difficult when accelerating then it would be if on the front, because you could lift the front a little when accelerating. So ask yourself, if you are driving around with a spare on; Do you want to be in more control when you are accelerating or would you rather be more prepared to control it if the spare blows.
If you are just running errands around town, and can take side streets then you probably won't get it fast enough to matter. If you NEED to highway speed commute, then that's when I would definitely want it on the rear.
