On a truck like that, there is a lot of electrical stuff back there.
When you say get the wheels wet, how wet are we talking? Is it just up into the rims a little bit, or are you to the point of bumper in the water and wheels below water to a point higher than the halfway up the wheel?
My concerns would be the following:
1. Rear brake drums for the emergency brake getting corroded up
2. Parking sensors (assuming bumper below water)
3. Compressor for air shocks
Granted, all these should be designed to accept moisture. A lot of water blows around while driving in heavy rain, etc. The breathers for the axle and compressor are up high by the fuel fill door. The electrical connectors should be water tight.....for the most part.
Suggestions:
1) pack electrical connectors with dielectric grease and reassemble to keep moisture out.
2) maybe use the parking brake to slow you down when stopping in addition to regular brakes to generate some heat and try to get the moisture out that way. This will keep the drum cleaner from rust buildup, exercise the cables and linkage, but will reduce the usable life of the shoes.
3) inspect breather hoses for dry rot or cracking an make sure they are going higher up like they are supposed to.