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Good question. Does the Esky or Denali have a dual inlet muffler?
If it is a single in, I don't see why it wouldn't work. I cant see GM changing the hanger location for the luxury models. Though weirder things have happened
I have both and did some looking, the escalade is definitely bigger diameter but other than that it looks the same. I think all it would need is an adapter to bolt up to the manifolds.